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Pyruvic peeling




Pyruvic peeling of the acid for the treatment of acne 

 

Journey to the discovery of a new formulation in the treatment of mild to moderate aging and photoaging 

 

Pyruvic Acid and 'a substance used for years successfully in clinics and hospital day of dermatology in many Italian hospitals where she' stated as the reference molecule, alone or in combination, in treatment of active phase in and its outcomes, of aging and photoaging. In that regard, there are numerous scientific publications made on national magazines and international (Dermatology outpatient JEADV Dermatologic Surgery Dermatology Times, etc). 

 

Because of its peculiar features in recent years, and 'began to assert in aesthetic medicine, becoming an additional means for the medical aesthetic that has widened the indications and the field of use. Pyruvic Acid (CH3COCOOH) and 'an alpha ketoacidosis to three carbon atoms, which has always been regarded as a discrete hydrogen power, having a pKa of 2.39 (logarithmic constant of dissociation), which makes it more' powerful glycolic and salicylic but less aggressive trichloroacetic boasting a pKa of 0.69. It's is naturally occurring in fermented fruit, apple vinegar and enters the Krebs cycle. Its corresponding alpha hydroxyacids and 'Lactic Acid (CH3CHOHCOOH), with whom and' always in dynamic equilibrium: therefore Pyruvic possesses both the characteristics of an acid than a ketone. It's a molecule' small 'and that' allows it to penetrate easily and effectively in most layers' deep in the skin. 

 

Another peculiarity 'of Pyruvic and' his lower capacity 'is associated with water molecules when compared to the family of alpha hydroxyacids. This "lipophilicity" gives great ability 'to enter the follicle where pilosebaceo can make bacteriostatic action, sebostatica and comedolitica. It's immediate deduction that the treatment of skin and oily or seborrheic decided draws benefit from treatment with topical Pyruvic. 

In the skin Pyruvic acid induces a decrease in intercellular cohesion corneocitario with detachment and consequent epidermal renewal. 

In dermal and 'proven his ability' to stimulate the activity 'of fibroblasts resulting in increased synthesis of collagen, elastin and gags and remodeling of the dermis. 

 

 

At high concentrations (60%, 70%) Pyruvic acid can 'give effect more' deep, how intense erythema and epidermolysis with dermo epidermal separation, manifested by the appearance of white frost. 

  

In my experience with Pyruvic acid peeling solution I used formulations of well balanced and varied in their potency due to exclusivity 'of the vehicles, so as to be very flexible, manageable and easily manageable. The broad availability 'of mergers (40% - 50% - 60%) allows to vary the depth' of the peeling and adapt with ease 'all'inestetismo the effect to be treated. 

 

In those circumstances the peeling of the acid Pyruvic located in aesthetic medicine indications in the treatment of seborrheic skin, impure, a trend acneica, thick skins, anaelastiche with texture and enlarged uneven pigmentation, scarring results in of acne and reduction of superficial wrinkles. 

 

Clinical studies performed on patients with acne in active mild to moderate photoaging and mild to moderate show that after a cycle of 6 peeling with Pyruvic acid solutions and 'possible to appreciate a significant clinical improvement of patients with acne associated with a clear decrease in seborrhoea, without notice a significant decrease in skin hydration. Colorimitreci examinations carried out before, immediately after and 15 days away from peeling made it possible to observe a greater light's skin of the face, the greater homogeneity' pigmentation, the net reduction of hyperpigmentation of periocular and perioral wrinkles, showing that in no subject was found a tendency towards hyperpigmentation.

 

 

The technique requires first of all peeling cleansing of the skin surface with solution and removal of the film hydrolipidic with alcohol or acetone, this operation much more 'important on thick skin and less oily and dry on those subtle, but nevertheless useful for remove any residual water which would change the corresponding nell'idrossiacido Pyruvic: The Lactic. Following the application (brush or gauze) in the concentration of Pyruvic appropriate depending on the type of skin el'inestetismo who must deal with approximately 40% for one share more 'superficial, 50% or 60% at a Action more 'deep. 

 

The time of application and 'very variable (from one to however many minutes) during treatment and' the need to monitor skin surface until the appearance of intense erythema and homogeneous layers, where appropriate, the substance on the areas most in 'slow penetration. And 'do not "look" a widespread frost with Pyruvic acid because' they do not need the results of clinical outcome. Reached the desired degree of erythema Pyruvic acid is inactive with a solution of baking soda and water, then remove everything with a simple rinse of the face. The neutralization of dovra 'from areas of skin that are more' reactive, such as around the eyes and sides of the nose or where you want to achieve a more 'superficial. It should be remembered that in some conditions, such as injuries acneiche being active, the Pyruvic acid has a higher degree of penetration and can 'and then determine the rapid appearance of frost in the follicle. 

 

This event and 'to be considered perfectly normal and conducive to a rapid improvement of the skin. Seguira 'the application of soothing cream-moisturizer with sun protection factor and the prescription of a home therapy with moisturizing products for the first few days, and subsequently with Pyruvic acid in low concentrations. With regard to side effects during the application you can 'have a burning sensation too intense at times by the patient who disappears immediately with the inactivation and vapors may be emitted pungent for conjunctival mucosa and upper respiratory. A session with Pyruvic acid can 'be repeated every 15-25 days for a period depending on the cases and claims, to obtain the desired result. 

 

What pleasantly surprised with this kind of peeling and 'rapid resolution of eritema, the appearance after 2-3 days of flaking a thin type furfuraceo easily be disguised with cosmetics, which lasts a few days but not least the forces patient to change lifestyle, and with a good compliance by the patient. 

It's also a peeling that no contraindications except in recurrent herpes, in diseases of connective and allergic dermatitis and irritation. It's peeling an effective, manageable and secure, with a unique mechanism of action due to its high lipophilicity, has minimal side effects, offers a wide scope and it poses as an additional tool available to the medical aesthetics than with scientific rigor turns to the solution of the imperfections of the face. 

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Glycolic: stimulates collagen growth more effectively than any of the other peels. It's small molecule allows it to slip beneath the epidermis to reach the collagen fibers below and results in 15%-25%  thickening over 12 weeks. Glycolic acid generally causes little or no visible peeling.

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(Product received may temporarily differ from image shown due to packaging update. Image will be revised, shortly)
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